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Topical melatonin for hair loss

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Topically applied melatonin shows some interesting results in reversing androgenic alopecia. (Hormone induced baldness.)

There's a part of me waiting for the other shoe to drop here, since DHT, the leading cause of hair loss, is a hair growth promoter itself.

But who knows, maybe it works?

Quote:Incubation of anagen mohair and cashmere follicles in the presence of melatonin or prolactin showed positive responses in hair shaft growth and protein synthesis to both signalling molecules.

http://www.ncbi.nlm.nih.gov/pubmed/22444695
Quote:Melatonin may also functionally play a role in hair-cycle control, as it down-regulates both apoptosis and estrogen receptor-alpha expression, and modulates MT2 and RORalpha expression in murine skin in a hair-cycle-dependent manner.

http://www.ncbi.nlm.nih.gov/pubmed/18078443

Quote:(2004) Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.

To the authors' knowledge, this pilot study is the first to show that topically applied melatonin might influence hair growth in humans in vivo.

http://www.ncbi.nlm.nih.gov/pubmed/14996107

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